Abstract
Using Modelling and Simulation for Planning and Evaluation of Health Systems needs the combination of state of the art modelling and simulation tools, which can be used in a modular way. In addition, big data sets are used to describe the status-quo of health systems. Together possibilities for prediction and strategic planning increase, while challenges for quality assessment and reproducible processes generate the need for new developed structures in research and implementation. The article gives an outline of approaches, developed within the Austrian DEXHELPP project and points out strategies for coping with these challenges.